Predicting IVF Success 101:
Univfy’s Fertility Chronicles is pleased to present an occasional blog series explaining the many fertility factors, such as age, ovarian reserve, body mass index, and others, that determine your personal probability of having a baby with IVF. Univfy IVF Prediction Tests analyze the sum total of all these factors unique to you to determine your personal probability of IVF success. We hope that explaining these factors will give you a better understanding of Univfy IVF Prediction Tests’ ability to help you and your fertility doctor make more informed and confident decisions about your fertility treatment. Welcome to the blog series, “Predicting IVF Success.”
---Mylene Yao, M.D., CEO and Co-founder, Univfy Inc.
Besides a woman’s age, what are top predictors of IVF success? Ovarian reserve and body mass index (BMI) are two that top the charts for IVF prediction. In the next several posts, we will look at ovarian reserve, in particular, as a fertility factor.
Physicians typically take ovarian reserve and body mass index (BMI) into account when starting an IVF cycle and adjust their stimulation protocol accordingly. No wonder: Ovarian reserve and BMI vary among women of all ages and together contribute approximately 20% to the overall picture of your chances of having a baby with IVF.
Ovarian reserve is typically discussed in the context of declining egg supply and egg quality that comes with age. Egg quality decreases with age, as an increasing proportion of eggs and embryos possess an abnormal number of chromosomes, or aneuploidy. As women get older, more of their eggs and embryos have aneuploidy, because the egg or resulting embryo is less able to correct errors that occur when its cells divide.
Ovarian reserve can be measured indirectly through three clinical tests: 1) The level of follicle stimulating hormone (FSH) on Day 3 of the cycle, 2) the number of “starter” antral follicles visible by ultrasound imaging of the ovaries at the beginning of the cycle, and 3) the level of anti-mullerian hormone (AMH).Let’s start by taking a closer look at the first two of these tests. We will look at the last test, anti-mullerian hormone (AMH), in the next blog in this series.
If your egg supply is low, your body still attempts to drive egg production by producing more FSH at an earlier time in the cycle. If FSH levels are higher than normal on Day 3 of the cycle, it is a good indication that ovarian reserve may be low. FSH is also given as injections to drive egg production in an IVF cycle.
While ovarian reserve is an important factor, your personal probability of pregnancy from IVF arises from the combination of multiple factors that are specific to you. Your ovarian reserve may be above average for your age, but you may have other fertility factors (body mass index, male factor, and others) that could result in a lower probability of pregnancy than predicted by ovarian reserve alone.
Likewise, while your ovarian reserve may be lower than average, if you don’t have a lot of other negative fertility factors, your actual chance of pregnancy may be higher than predicted by ovarian reserve testing alone. Univfy PreIVF and Univfy PredictIVF are able to provide the composite picture of multiple factors to determine your personal probability of IVF success.
Visit Considering IVF for more fertility health information and interactive tools to personalize your fertility path.