Mary is aiming at starting her family. She and her husband have been working hard for two years to conceive. They did get pregnant, once, with a pregnancy ending in miscarriage. Fertility tests have not indicated a problem.
For a woman like Mary, things look normal, but they are not. On the surface, everything is in place for pregnancy, but conception does not happen. The most common reason for this is aneuploidy.
Aneuploidy is an abnormal number of chromosomes in an embryo. Normally 23 pairs of chromosomes, including the X and Y, are evenly duplicated between cells as the embryo forms. In aneuploidy, one or more chromosomes are missing or duplicated--with loss of balance in the DNA coding for the embryo.
Aneuploidy is extraordinary in how common it appears. Most embryos, after the first few days of development, are affected by aneuploidy, and only a few embryos are truly healthy and show normal numbers of chromosomes.
Aneuploid embryos usually do not grow because the chromosomes are so jumbled. Those few that do grow often result in miscarriage. Fewer still, those that grow beyond the first trimester result in clinical aneuploidy, such as Down Syndrome.
Comprehensive Chromosome Screening (CCS) is a new way of identifying the healthiest embryos for transfer during in vitro fertilization (IVF). This exciting new technology enables the routine transfer of a single healthy embryo with very low risk and with dramatic improvements in implantation and pregnancy rates.
With Comprehensive Chromosome Screening, it is possible to determine whether there is a balanced set of chromosomes, an euploid embryo, at an early stage of development. With an euploid embryo, a woman has an excellent chance of conceiving and carrying a healthy baby to term. In 2012, Pacific Fertility Center’s clinical pregnancy rate was 74.5 percent per transfer with CCS-screened embryos in women 40 and under. Three out of four times, in this patient group, an embryo produced a pregnancy.
In addition to improving IVF pregnancy rates, Comprehensive Chromosome Screening helps:
Mary and her husband underwent IVF with Comprehensive Chromosome Screening and are now pregnant with a son. The treatment produced 12 embryos, out of which two were healthy euploid embryos. One was transferred, resulting in her pregnancy, and the second is in cryo-storage, offering a good chance for a second child. In one cycle of IVF, Mary and her husband produced enough healthy embryos to enable a great start to their family.